GameHow
The Sims 4: Get to WorkTakes your character inside a secret desert laboratory to analyze samples, synthesize serums, and build inventions.
Kerbal Space ProgramIncludes a Science Mode where you attach barometers to spacecraft and run experiments across planetary biomes.
SubnauticaPlaces you on an ocean planet to build underwater research bases, scan alien fauna, and study biological samples.
Potion Craft: Alchemist SimulatorLets you grind reagents with a mortar and pestle and control cauldron heat in a medieval laboratory.
LifeSimPuts you in a real city on a 3D map where you talk with lab coworkers in your own words. There are no lab interiors or mini-games.